Diagnostic problem schiller emphasized that this, also, was a poor choice, because the name was used loosely to include all varieties 01 metastatic carcinoma to the ovary. Krukenberg tumor a multidisciplinary approach a case. He considered this tumor to be a fibrosarcoma containing large epithelioid cells enclosing mucin, which induced him to add the name mucocellulare carcinomatodes. Krukenberg tumors accompanied by gestational hypertension are rare and have a poor patient prognosis. Krukenberg tumor is more commonly observed among women in the fifth decade, with an average age of presentation at 45 years of age. Ovarian cancer occurs in one in 8000 to one in 25,000 pregnancies. The tumor presented certain characteristics of form and growth not seen in other ovarian tumors. Krukenberg tumor is usually but not always a bilateral involvement of ovaries from metastatic deposit from adenocarcinoma of stomach and rarely from other gastrointestinal gi and non gi organs. Occasionally krukenberg tumors have endocrine function and, as a consequence, some patients demonstrate hirsutism and virilization. Histology shows typical mucusproduction and numerous signetring cells. This study aimed to identify the prognostic factors affecting the survival of patients with kts of colorectal origin who receive cytoreductive surgery. It is still uncertain whether surgical resection of ovarian metastases andor primary tumor could. There is a lack of description in the literature related to the pathway. In 1896, he was the first to report the primary malignancy in the ovaries.
May 10, 2012 from mucin secreting tumors, stomach and colon krukenberg tumors may be secondary to breast 39. The stomach is the primary site in the majority of krukenberg tumor. Clinical analysis of krukenberg tumours in patients with. The role of surgical excision for the krukenberg tumour. If you have problems viewing pdf files, download the latest version of adobe reader.
Because these tumors are secondary metastases, rather than primary tumors, identifying. Krukenberg tumor is a metastatic cancerous development spread from stomach to ovary. Krukenberg tumor article about krukenberg tumor by the free. Although krukenberg tumor can occur in people of all age groups, the average age is fixed at 45 years. An adnexal mass in pregnancy is a malignant tumor in 25% of cases. Only 10% of patients survive more than two years after diagnosis. In most krukenberg tumor cases, stomach is the main primary site. Jan 14, 2017 a krukenberg tumour kt is defined as an ovarian metastasis from a gastrointestinal adenocarcinoma and suggests a terminal condition. Assessment revealed no intrauterine pregnancy and a small left ovarian cyst. Krukenbergs tumor article about krukenbergs tumor by.
In 1896 friedrich krukenberg described a tumor of the ovary which he called fibrosarcoma mucocellulare carcinomatodes. Dec 19, 20 a krukenberg tumor can vary in terms of its depth and the number of metastatic lymph nodes derived from the primary tumor, and these factors influence survival 21, 22. Download home journal of gastrointestinal oncology. At the surgery was found that both ovaries were infiltrated. According to a study of a large series of krukenberg tumors, the primary tumors comprise gastric 76%, colorectal 11%, breast 4%, biliary tract 3%. Krukenberg tumor definition of krukenberg tumor by. In case of gastric carcinoma diagnosed in women, a regular gynecological examination is necessary due to a. The prognosis of a patient with krukenberg tumor is extremely poor with average survival time between 3 and 10 months.
A krukenberg tumor can vary in terms of its depth and the number of metastatic lymph nodes derived from the primary tumor, and these factors influence survival 21, 22. The primary tumor of the krukenberg tumor can be occult and can go undetected for several years after oophorectomy. Files are available under licenses specified on their description page. A krukenberg tumor is a rare and potentially deadly cause of elevated serum. Krukenberg tumor is an uncommon metastatic tumor of the ovary. Krukenberg tumor survival rate, prognosis, symptoms, treatment. She was referred recurrent cholangiocarcinoma presenting as ovarian krukenberg tumor chuanchi shih 1, yuhcheng yang 1,2,3,4, jerry chengyen lai 4, yuhui huang 1, taoyeuan wang 5, kungliahng wang 1,3,6 1 department of obstetrics and gynecology. This case illustrates multimodality imaging of a pathologically proven krukenberg tumor of gastric origin. Krukenberg tumor article about krukenberg tumor by the.
Complication of ovarian tumors torsion common with dermoidfibroma severe abdominal painvomitting rupture haemorrhage impaction infection 41. An uptodate understanding of the krukenberg tumor mechanism. This article is from experimental and therapeutic medicine, volume 7. Alternatively, you can also download the pdf file directly to your computer, from where it can be opened using a pdf reader. Genetic and rare diseases information center gard po box 8126, gaithersburg, md 208988126.
Of the 43 patients, the median age at diagnosis of krukenberg tumor was 42 years range, 2172. A case report of krukenberg tumor s secondary to adenocarcinoma of gall bladder from krukenberg to todaythe ever present problems posed by metastatic tumors of the ovary, part i. It is important due to a high risk of metastatic changes localized. Survival benefit of metastasectomy for krukenberg tumors from. Krukenberg tumor arising from bilateral lobular carcinoma. The route of metastatsis of this rare condition is still not proven. The krukenberg tumor represents ovarian metastases associated with gastric cancer or other gastrointestinal malignancies. Gastric adenocarcinoma, especially at the pylorus, is the most common source. Pdf ovarian metastasis was described the first time by friedrich ernst krukenberg in 1896.
Krukenberg tumor is a metastatic signet ring cell adenocarcinoma of the ovary, accounting for 1% to 2% of all ovarian tumors. Krukenberg tumors of gastric origin frequency compared to. It is essential to rule out other ovarian malignancy to avoid the misdiagnosis and management of the krukenberg tumor. Management of synchronous krukenberg tumors from gastric. Gastric cancer has been reported as the most frequent primary source of a krukenberg tumor. Despite the improved prognosis as a result of the early diagnosis, radical surgery, and the advances in adjuvant therapy, death from gastric cancer is almost always due to the recurrent disease 7, 8, 9. A tumor of the ovary that is caused by the spread of metastatic cancer of the gastrointestinal tract, characteristically from the stomach. Metastatic lesions within the ovary constitute a serious diagnostic problem in daily practice. Survival benefit of metastasectomy for krukenberg tumors. The colon and stomach are the most common primary tumors to result in ovarian metastases, followed by the breast, lung, and contralateral ovary. The treatment of metachronous krukenberg tumor mkt from gastric cancer remains unexplored.
Only about 1% to 2% of all ovarian tumors are krukenberg tumor but in some countries like korea, japan and china where the incidence of stomach cancer is very high this rare disease is not so uncommon 5 6. For language access assistance, contact the ncats public information officer. A krukenberg tumour kt is defined as an ovarian metastasis from a gastrointestinal adenocarcinoma and suggests a terminal condition. We present an interesting case of krukenberg tumor in a woman years after partial gastrectomy due to stomach cancer. A case report of krukenberg tumors secondary to adenocarcinoma of gall bladder from krukenberg to todaythe ever present problems posed by metastatic tumors of the ovary, part i. All stage iv stomach cancer krukenberg tumours messages. Krukenberg carcinoma genetic and rare diseases information. A rare krukenberg tumor arising from a primary adenocarcinoma of. Patients of all age groups may develop krukenberg tumor. A krukenberg tumor generally refers to a metastatic carcinoma of the ovary and is characterized by the presence of mucinfilled signetring cells accounting for at least 10% of the tumor. Krukenberg krukenberg, friedrich, german pathologist, 1871. From mucin secreting tumors, stomach and colon krukenberg tumors may be secondary to breast 39. Serum ca125 level can help to predict the prognosis. The pdf file you selected should load here if your web browser has a pdf reader plugin installed for example, a recent version of adobe acrobat reader.
Appearance of krukenberg tumor from gastric carcinoma. Friedrich ernst krukenberg 18711946, german physician. Krukenberg tumor was first described as a new type of primary ovarian malignancy by friedrich ernst krukenberg. Apr 11, 2020 a krukenberg tumor is a type of ovarian tumor which starts in another area of the body and migrates to the ovaries. Krukenberg tumor demonstrates the selective spread of cancers. Surgical removal of isolated ovarian metastasis without peritoneal involvement is associated with improved outcomes. The rationale of surgical resection and perioperative treatments in a multicenter western experience. Krukenberg tumors are often over 80% found in both ovaries, consistent with its metastatic nature. Worldwide, they account for about 1% of all ovarian neoplasms. A krukenberg tumor from an occult intramucosal gastric. Krukenberg tumor refers to gastrointestinal cancer metastatic to the ovaries and its prognosis is uniformly poor. Krukenberg tumors are often over 80% found in both ovaries, consistent.
Stomach is the primary site in most krukenberg tumors 70%. The incidence of krukenberg tumor is estimated to be approximately 0. Is a surgical approach justified in metachronous krukenberg tumor. Krukenberg tumour kt, which represents carcinoma in the ovary, is an uncommon. Krukenberg tumor presenting as back pain and a positive. Krukenberg tumor in a 22 year old patient with primary. Medical records of patients who had received cytoreductive surgery and had been pathologically diagnosed with. Krukenberg tumour kt is clinically defined as any ovarian metastatic carcinoma derived from a primary malignancy usually from the gastrointestinal. This case report concerns a 25yearold pregnant woman referred at 24 weeks of gestation with an ovarian tumor. This study aims to evaluate the frequency of krukenberg tumors of gastric origin versus those of colorectal origin.
Surgery is the main treatment in the absence of metastases for medically fit patients. Hi there, my mother is 52 years old, she was diagnosed in sept. Krukenberg tumor is a rare metastastic tumor of the ovary. Six years after this, it was known that these ovarian malignancies had their origin in the metastatic gastrointestinal tract. A krukenberg tumor refers to a malignancy in the ovary that metastasized from a primary site, classically the gastrointestinal tract, although it can arise in other tissues such as the breast. Metastatic factors of 43 cases of metachronous krukenberg tumor were analyzed with univariate and multivariate methods. Krukenbergtumor is a metastatic ovarian tumor with its primary site being the gastrointestinal tract. Genetic and rare diseases information center gard po box 8126, gaithersburg, md 208988126 tollfree. In most cases, the cancer starts from the ovary itself while in few cases accounting for 1 to 2% of the total, the cancer metastasizes into the ovary. The pathogenesis of krukenberg tumor formation is still in its hypothetical stage though the current understanding suggests lymphatic, hematogenous and transcoelomic route as the 3 major route of metastasis. Carcinomas of colon, appendix, and breast mainly invasive lobular carcinoma are the next most common primary sites 2. Krukenberg definition of krukenberg by medical dictionary.
To download the pdf, click the download link below. Around five to six percent of ovarian cancers present as krukenberg tumors, and the prognosis for patients with this type of tumor is not good. At the present time most observers consider it to be secondary to carcinoma in some portion of the gastrointestinal tract. The development of the krukenberg tumor is not from general gastric cancer, but it is a specific form of cancerous growth arises from signet ring cell carcinoma of the stomach and spread to adenocarcinoma of the ovary. Recurrent cholangiocarcinoma presenting as ovarian krukenberg. Krukenbergs tumor article about krukenbergs tumor by the. A krukenberg tumor is a rare tumor of the ovary derived from metastatic gastrointestinal tissue, most common from gastric cancer.
Recurrent cholangiocarcinoma presenting as ovarian. Pdf an uptodate understanding of the krukenberg tumor. Krukenberg tumor is typically free of surface adhesions or peritoneal deposits unlike other ovarian metastasis. Cholangiocarcinoma presenting as ovarian krukenberg tumor chuanchi shih 1, yuhcheng yang 1,2,3,4, jerry chengyen. Here, we report a very rare case of bilateral krukenberg tumors of the ovaries arising from a primary adenocarcinoma of the. Diagnosing and treating krukenberg tumor international journal of. Krukenbergs tumorsaremetastatic tumorsoftheovarythat account for510% ofovarian tumors andthatcausemajor problems inradiologic orpathologic diagnosis 5. Krukenberg tumor presenting as back pain and a positive urine. Because these tumors are secondary metastases, rather than primary tumors, identifying one means. Krukenberg maintained that the tumor was primary in the ovary, a view that has been much discussed and opposed. Abstract krukenberg tumors accompanied by gestational hypertension are rare and have a poor patient prognosis.
Krukenberg tumor is named after friedrich ernst krukenberg who described five cases of krukenberg tumors in 1896 while working as a student in a laboratory in germany. Krukenberg tumor definition of krukenberg tumor by medical. Our case confirms that every woman with history of cancer should remain under gynecological control. Clinical characteristics and prognostic analysis of krukenberg tumor. Even if the historical timeline dates back to sir james. Summary the aim of the study was to discuss the case of krukenberg tumor in a patient, eight years after the diagnosis and surgical treatment of gastric carcinoma. Treatment of patients with krukenberg tumor is controversial.
Krukenberg tumor 8 years after surgical treatment emerich. All structured data from the file and property namespaces is available under the creative commons cc0 license. Medical records of patients who had received cytoreductive surgery and. A krukenberg tumor is a type of ovarian tumor which starts in another area of the body and migrates to the ovaries. A case report of krukenberg tumor s secondary to adenocarcinoma of gall bladder also, ovarian metastases, including krukenberg tumors, may be mistaken as a solid sexcord stromal tumor and can appear as solid or complex ovarian. We have concluded that there was no safe period after which distant metastases may be excluded. A case of virilization induced by a krukenberg tumor from. Krukenberg tumor, also known as carcinoma mucocellulare, refers to the signet ring subtype of metastatic tumor to the ovary.
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